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The trials of homeopathy*
Based on a prize-winning PhD thesis, this book provides a comprehensive and rigorous review of homeopathic research. It discusses historical and contemporary trials in terms of their underlying principles, research methods and clinical relevance. Includes extensive bibliographies.
Contents
1.2.1. Homeopathy's place in the history of therapeutics.......................... 3
1.2.2. Homeopathy and the development of clinical evaluation ............... 4
1.2.3. Is homeopathy clinically relevant? ................................................. 5
3.1. The main objections ....................................................................................35
3.2. Hahnemann and alchemy ............................................................................37
3.3. Pharmacology..............................................................................................39
3.3.1. Similars and signatures .................................................................39
3.3.2. Drug tests .....................................................................................41
3.3.3. Therapeutic poisons and the minimum dose .................................42
3.3.4. Drug preparation...........................................................................4
3.4.1. Acute 'miasms' ............................................................................. 47
4.3. Nosological and pathological homeopathy ..................................................
4.4. Parahomeopathic concepts and homeopathic neorationalism......................72
4.4.1. Organ remedies .............................................................................72
4.4.2. Biochemic tissue salts ...................................................................72
4.4.3. Constitutional biotypes and morphology.......................................73
4.5.1. Layer theory..................................................................................77
4.5.2. Sequential therapy ......................................................................... 78
5.4. Historiography of homeopathic trials ......................................................... 91
5.5. Justification for reviewing early homeopathic trials ................................... 93
6. The earliest observational studies, 1821-35 ....................... 101
6.3. Germanic trials ......................................................................................... 104
6.3.1. Berlin 1821: Stapf, Wislicenius ................................................. 104
6.3.2. Vienna 1828: Marenzeller .......................................................... 104
6.3.3. Naples 1828: de Horatiis........................................................... 105
6.3.4. Naples 1829: de Horatiis........................................................... 105
6.3.5. Tulzyn 1829: Herrmann..............................................................106
6.3.6. St Petersburg 1829-30: Herrmann ............................................. 106
6.3.7. Munich 1830-31: Attomyr & Ringseis .......................................106
6.4.1. Lyons 1832: Gueyrard.................................................................107
6.4.2. Paris 1834: Andral ......................................................................108
6.4.3. Paris 1835: Andral ......................................................................109
6.4.4. Paris 1834: Simon, Curie ............................................................110
6.5. Discussion .................................................................................................111
7. Comparisons with allopathy, 1844-86 ................................113
7.1. Introduction...............................................................................................113
7.2. Results.......................................................................................................114
7.2.1. Miskolz, Austro-Hungary 1844: general.....................................117
7.2.2. St Petersburg 1847-54: general...................................................117
7.2.3. Paris 1847^9: pneumonia..........................................................118
7.2.4. Paris 1849: cholera......................................................................120
7.2.5. Paris 1849-51: general................................................................120
7.2.6. Vienna 1850-59: pneumonia ......................................................122
7.2.7. London 1854: scarlet fever prevention........................................123
8.2. Placebo-controlled provings ...................................................................... 138
8.3. Therapeutic trials involving placebo ......................................................... 142
8.3.1. Placebo-controlled trials.............................................................. 142
8.3.2. Trials of placebo without homeopathic treatment ....................... 142
8.4. Placebo in homeopathic practice ............................................................... 144
9. Adoption of the biomedical research perspective,
1914-53 ............................................................................. 155
9.3. USA 1914-38 ........................................................................................... 156
9.3.1. Boston 1914: scarlet fever .......................................................... 160
9.3.2. Boston 1914-16: scarlet fever ................................................... 160
9.3.3.Bostonl915:diphtheria.............................................................. 161
9.3.4. Boston 1917: scarlet fever........................................................... 161
9.3.5. Boston 1921-23: mumps............................................................. 162
9.5. Great Britain 1941-53..............................................................................167
9.5.1. Glasgow 1941: diphtheria .......................................................... 168
9.5.2. Glasgow & London 1941^2: mustard gas burns ....................... 169
9.5.3. Burton-on-Trent, 1951—53: surgical tuberculosis ....................... 171
11.2. Language restrictions.............................................................................. 185
11.3. Inclusion and exclusion criteria............................................................... 186
11.3.1. Therapy definition .................................................................... 186
11.3.2. Medicine definition .................................................................. 186
11.3.3. Trial design............................................................................... 186
11.4. Data extraction ....................................................................................... 187
11.5. Representing strength of results.............................................................. 188
11.6. Methodological quality Instrument ......................................................... 189
12. Results .............................................................................. 195
12.1. Design..................................................................................................... 196
12.2. Intrahomeopathic differences...................................................................198
12.3. Treatment effects .................................................................................... 201
12.4. Adverse reactions.................................................................................... 202
12.5. Holism, quality of life and economic evaluation .................................... 203
12.6. Methodological quality ........................................................................... 204
12.6. l Comparison with other quality scales ........................................ 208
12.7. Highest quality trials................................................................................209
12.8.Clinicalrelevance ....................................................................................210
Trial reports 1821-1954 (Part II) .....................................................................253
General references..., .......................................................................,.,,,,,,,,,,....276